Case Illustration of the Natural History of Left Dominant Arrhythmogenic Cardiomyopathy

Background: Arrhythmogenic left ventricular cardiomyopathy is an increasingly recognized cause of recurrent myocarditis, a mimicker acute coronary syndrome, and important malignant arrythmias heart failure. Desmoplakin protein that critical to maintaining the structural integrity myocardium. Disruption desmoplakin leads fibrofatty infiltration myocardium which congestive failure, cardiac arrhythmias, sudden death. However, often misdiagnosed, resulting in significant morbidity mortality. We report 2 contrasting cases illustrating natural history—hot cold phases—of arrhythmogenic cardiomyopathy. Case Series: The first case demonstrates common phenotypic presentation manifested as myocarditis myocardial injury representing hot phase. second undulating course chronic systolic failure arrhythmias Conclusion: manifests spectrum disease processes involve right, left, or both ventricles. Mutations gene are associated with dominant Diagnosis remains difficult condition has no signature clinical presentation, imaging findings variable.